; Trilk, J.L. The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins. MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Aleksi Tornio, Janne T. Backman, in Advances in Pharmacology, 2018. This protein is involved in the breakdown of stimulants, drugs, nutrients, and other xenobiotics. Specifically, it is involved in the metabolism of the xenobiotics caffeine, aflatoxin B1, and acetaminophen. Based on the studies selected for the aim of the current systematic review, we may form adequate conclusions regarding the impact of select SNPs on the ergogenic and anxiogenic consequences and habitual use of caffeine in humans. This study showed in actual people that curcumin decreased CYP1A2 activity by ~30%, and urinary excretion of caffeine metabolites 17X and 1-methylxanthine was decreased by 36.4% and 31.2% respectively. Josse, A.R. Fredholm, B.B. polymorphism; anxiety; ergogenic; adenosine receptor; cytochrome P450; caffeine; pharmacogenomics, Prog. 3.1 CYP1A2. The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins. CYP1A2 is inhibited by- chamomile, cumin (curcumin), dandelion, oral contraceptive, peppermint, St. John’s wort, turmeric. CYP1A2 is also induced (activated) by cruciferous veggies such as cabbage, cauliflower, and broccoli. Lower activity of CYP1A2 in South Asians appears to be due to cooking these vegetables in curries using ingredients such as cumin and turmeric, ingredients known to inhibit the enzyme. ; Armijo-Olivo, S.; Thie, N.; Seikaly, H.; Boulanger, P.; Wolfaardt, J.; Major, P. Morphologic and functional changes in the temporomandibular joint and stomatognathic system after transmandibular surgery in oral and oropharyngeal cancers: Systematic review. ; Ryan, E.J. ; O’Connor, P.J. (Edward J. Ryan), P.C.D., A.E.C., J.R.E., E.J.R. † The follow-up clinical studies in healthy volunteers demonstrated that the expected In contrast, two recent stud-ies showed negative results. Giersch, G.E. Influence of a cyp1a2 polymorphism on post-exercise heart rate variability in response to caffeine intake: A double-blind, placebo-controlled trial. ; Hohoff, C.; Heatherley, S.V. • The induction effects of AZD7325 on CYP1A2 and CYP3A4 have not been systematically studied. WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: • AZD7325 is an orally administered, potent, selective gamma-amino-butyric acid (GABA(A) ) α2,3 receptor modulator intended for the treatment of anxiety. (Edward J. Ryan), P.C.D., A.E.C., J.R.E., E.J.R (Emily J. Ryan). Metabolized by CYP1A2 and 2D6. WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • AZD7325 is an orally administered, potent, selective gamma‐amino‐butyric acid (GABA A) α2,3 receptor modulator intended for the treatment of anxiety. Further, while caffeine is generally well tolerated, some individuals report feelings of anxiety following consumption . Please note that many of the page functionalities won't work as expected without javascript enabled. Validations were done by J.L.F., E.J.R. ; Manring, M.M. In alternative models, the following factors Women with high self-reported caffeine sensitivity and low daily caffeine consumption, Genes not typically associated with sleep disturbance were implicated in coffee-attributed insomnia, 25 M and 13 F recreational cyclists from James Madison University, 370 individuals from Puglia, Italy and 843 individuals from Friuli Venezia Region, Italy, 10 men and 9 women elite basketball players, 162 non/low and 217 medium/high caffeine consumers, 185 healthy Caucasian nonsmokers and 51 smokers, Caffeine ingestion increased peak and mean power in both, 31.3% of C-allele carriers reported increased nervousness after caffeine ingestion, Systolic blood pressure (BP) increased with caffeine ingestion only among individuals with, No difference in heart rate variability between, 57 subjects with type 2 diabetes (T2D) and 146 non-T2D, CYP1A2 enzyme activity was significantly higher in T2D compared to control group (, Caffeine supplementation reduced 40 km time greater in. ; Casa, D.J. ; Mullings, E.L.; Maxfield, P.J. (Emily J. Ryan) The methodology was formed by J.L.F., E.J.R. In a randomized placebo-con-trolled pilot study with 12 generalized anxiety disorder (GAD) patients (Andreatini et al., 2002), valerian, diaze-pam, and placebo did not show any difference in change of ; Ward, N.C.; Hodgson, J.M. The statements, opinions and data contained in the journals are solely The effects of coffee consumption on health have not been firmly established. Forty-three anxiety disorder patients (DSM-III) who completed the Hopkins Symptom Checklist (SCL-90-R) and a caffeine questionnaire were compared to 124 medical inpatients. Our systematic review has a number of strengths. The general linear univariate model (analysis of covariance) was used to determine the ef-fects of antipsychotic doses and CYP1A2 genotype on LUNSERS total score. Coffee tolerance and coffee withdrawal syndromes are common and linked to the antagonist effect of caffeine on the adenosine receptor (2). Of these, 2115 were duplicates; therefore, 1417 were initially screened to exclude reviews, conferences and editorials (, The characteristics and the results of the included studies are presented in, The risk of bias assessment results can be found in, Out of the 16 non-RCTs, one showed a high risk of bias [, Six of the included studies reported genetic variation associated with habitual use [, Eight of the included studies reported data on genetic variation and anxiety/side effects of caffeine [, Eight of the included studies investigated the effects of genetic variability on the ergogenic consequences of caffeine [, Three of the included studies investigated the effect of the, Three additional studies were included in the present review [. Sachse, C.; Brockmoller, J.; Bauer, S.; Roots, I. Functional significance of a C→A polymorphism in intron 1 of the cytochrome p450 cyp1a2 gene tested with caffeine. ; Boerwinkle, E.; Chanock, S.; Chatterjee, N.; et al. ; Bolton, D.J. ; Ziegenfuss, T.; Kalman, D.; Kreider, R.; Campbell, B.; Wilborn, C.; Taylor, L.; Willoughby, D.; Stout, J.; Graves, B.S. (Emily J. Ryan), and the resources were done by J.L.F., E.J.R. Often people with more severe … CYP1A2 codes for a protein that belongs to the Cytochrome P450 family. Margulis, A.V. ; Womack, C.J. Associations between polymorphisms in the ahr and cyp1a1-cyp1a2 gene regions and habitual caffeine consumption. ; Gotzsche, P.C. CYP1A2 is an important enzyme involved in the activation of tobacco-specific nitrosamines (5,6). ; Heath, A.C.; Montgomery, G.W. (Emily J. Ryan), and formal analysis were done by J.L.F., E.J.R. The most common caffeine-containing beverages and foods are coffee, tea, cola, chocolate, and energy drinks (3–5). Domschke, K.; Gajewska, A.; Winter, B.; Herrmann, M.J.; Warrings, B.; Muhlberger, A.; Wosnitza, K.; Glotzbach, E.; Conzelmann, A.; Dlugos, A.; et al. ; Ryan, E.J. Effect of caffeine on sport-specific endurance performance: A systematic review. CYP1A2 enzyme activity was much more markedly increased in Sprague-Dawley than Wistar rats and CYP1A1 activity was induced to similar levels. Ganio, M.S. ; D’Lugos, A.C.; El-Sohemy, A.; Luden, N.D. Caffeine and 3-km cycling performance: Effects of mouth rinsing, genotype, and time of day. Womack, C.J. This indicates that both the RCTs and the non-RCTs may provide fairly good quality evidence. An increased risk of spontaneous abortion (3), cardiovascular disease (1), hypertension (4) and cancer (1) have been … In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. Find support for a specific problem on the support section of our website. ; El-Sohemy, A.; Womack, C.J. CYP1A2 is induced by- cruciferous veggies: broccoli., cabbage, cauliflower; polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke. CYP1A2 Location- mainly in the liver, also the lungs and pancreas. CYP1A2 metabolizes- Caffeine; Drugs: clozapine, Cymbalta, MDMA (ecstasy), olanzapine, tacrine, theophylline, Tylenol (acetaminophen), Wellbutrin, Zyprexa; Hormones: bilirubin, estrogens (estrone and estradiol), melatonin, and uroporphyrinogen; Toxins: aflatoxin B1, aromatic heterocyclic amines, polycyclic aromatic hydrocarbons (PAHs). Ergogenic effects of low doses of caffeine on cycling performance. ; Evershed, R.P. Guest, N.; Corey, P.; Vescovi, J.; El-Sohemy, A. Caffeine, cyp1a2 genotype, and endurance performance in athletes. • The induction effects of AZD7325 on CYP1A2 and CYP3A4 have not been systematically studied. Genome-wide association scans have implicated several indexed SNPs in caffeine consumption. We use cookies on our website to ensure you get the best experience. In the model, the antipsychotic dose was used as a covariate and the CYP1A2 genotype as a factor. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. Pirastu, N.; Kooyman, M.; Robino, A.; van der Spek, A.; Navarini, L.; Amin, N.; Karssen, L.C. ; Luden, N.D.; Saunders, L.J. ; Kivipelto, M. Caffeine as a protective factor in dementia and alzheimer’s disease. Such a systematic review may provide a basis for further interdisciplinary approaches and future directions. This research received no external funding. Bohn, S.K. CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine. Adenosine-dopamine interactions revealed in knockout mice. Single nucleotide polymorphisms in or near the cytochrome P450 (, Caffeine (1,3,7-trimethylxanthine) is one of the most widely used drugs in the world and is available in many mediums for consumption. ; Hartling, L. Assessing Risk of Bias and Confounding in Observational Studies of Interventions or Exposure: Further Development of the RTI Item Bank. ; Deckert, J.; Nutt, D.J. For writing—original draft preparation, the contributions were from J.L.F., E.J.R. Inhibits CYP1A2 and 2C19. Vegetables such as cabbages, cauliflower and broccoli are known to increase levels of CYP1A2. independently evaluated the risk of bias of the non- randomized controlled trials (RCT) via the 13-item tool developed by the Research Triangle Institute (RTI), Evidence-based Practice Center [, The results of the data extraction procedure are shown in, The reporting of the available information in this systematic review is shown in a PRISMA checklist in, The entire search yielded 3532 records. For example, the chronic consumption of coffee has been associated with cognitive performance and cardiovascular health [, Athletes have long utilized caffeine as an ergogenic aid [. Department of Movement Science, Chatham University, Pittsburgh, PA 15232, USA, FAME Laboratory, Department of Exercise Science, University of Thessaly, GR42100 Trikala, Greece, Department of Exercise Physiology, West Virginia University School of Medicine, West Virginia University, Morganton, WV 26506, USA. Djordjevic, N.; Ghotbi, R.; Bertilsson, L.; Jankovic, S.; Aklillu, E. Induction of cyp1a2 by heavy coffee consumption in serbs and swedes. Jenkins, N.T. ; Juni, P.; Moher, D.; Oxman, A.D.; Savovic, J.; Schulz, K.F. 28 Caffeine is a validated phenotyping agent used to assess the activity of CYP1A2. ; Clarke, M.J.; Higgins, J.P. Characteristics of meta-analyses and their component studies in the cochrane database of systematic reviews: A cross-sectional, descriptive analysis. Childs, E.; Hohoff, C.; Deckert, J.; Xu, K.; Badner, J.; de Wit, H. Association between adora2a and drd2 polymorphisms and caffeine-induced anxiety. However, the inclusion of non-peer-review data may have itself introduced bias, given that there was available peer-reviewed evidence [, In conclusion, our search has provided evidence that the. Eskelinen, M.H. Our dedicated information section provides allows you to learn more about MDPI. You seem to have javascript disabled. ; Gordon, S.D. WHATTHIS STUDY ADDS †Thein vitro studies showed that AZD7325 was a moderate CYP1A2 inducer and potent CYP3A4 inducer. ; Klau, J.F. ; Cafarelli, E. Caffeine increases time to fatigue by maintaining force and not by altering firing rates during submaximal isometric contractions. The influence of cyp1a2 genotype in the blood pressure response to caffeine ingestion is affected by physical activity status and caffeine consumption level. Psychiatry, Cochrane Handbook for Systematic Reviews of Interventions, Help us to further improve by taking part in this short 5 minute survey, Moderation and Mediation Analysis of the Relationship between Total Protein Concentration and the Risk of Depressive Disorders in Older Adults with Function Dependence in Home Care, The Acute Effects of Caffeinated Black Coffee on Cognition and Mood in Healthy Young and Older Adults, Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study, The Role of Genetics in Moderating the Inter-Individual Differences in the Ergogenicity of Caffeine, The Impact of Caffeine and Coffee on Human Health, https://www.mdpi.com/2072-6643/10/10/1373/s1, http://www.effectivehealthcare.ahrq.gov/reports/final.cfm, http://creativecommons.org/licenses/by/4.0/, 102 healthy individuals (M = 51 and F = 51) who consumed less than 300 mg caffeine per week, Association more pronounced among current smokers compared to nonsmokers, Eight loci, six being novel, met genome-wide significance (log, 126 Healthy Serbians, 64 nonsmoking (from their previous study), Startle magnitude highest for unpleasant pictures and lowest for pleasant pictures across, Females of this group had higher startle magnitudes than males, 57 M and 57 F healthy individuals controlled for anxiety sensitivity, Prepulse inhibition was influenced by genetics (, 20 male subjects between age of 18–45 years, Subjects who consumed >400 mg caffeine compared to who consumed <100 mg caffeine were more likely to be carriers of T, C, or T alleles for rs6968865, rs4410790, and rs2472297, respectively; corresponding Odds Ratios and 95% confidence intervals (CIs) were 1.41 (1.03, 1.93), 1.41 (1.04, 1.92), and 1.55 (1.01, 2.36). 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